Personalised Medicine – Pharmacogenomics
Pharmacogenomic (PGx) testing can help you get on the right medication at the right dose, the first time.
Your genetic make up (your DNA) provides a crucial role in how your body responds to medication.
Pharmacogenomic (PGx) DNA testing empowers you and your healthcare provider to develop a tailored treatment plan for maximum effectiveness.
How Does Pharmacogenomics (PGx) work?
Medication can be a powerful tool to manage health conditions. Everyone processes (metabolises) medications at different rates. While the general dosage, suggested by medication manufacturers, is designed to minimise side-effects, it may not suit your personal requirements.
If a group of patients are given the same medication at the same dose, they will react in four different ways:
- They drug will work but will cause side effects
- The drug won’t work and will also cause side effects
- The drug won’t work but there will be no side effects
- The drug will work and there will be no side effects
Depending on your unique genetic makeup, you may process a medication:
- Faster than normal, which may cause the medication to not provide the desired symptom relief
- Slower than normal, which may increase the risk of side-effects
Adjusting your medication and dosage can alleviate symptoms and mitigate side effects.
If this performed through a trial-and-error approach, this can:
- be time-consuming
- be financially taxing
- increase the possibility of an adverse drug reaction
- have significant social impact on families
PGx testing provides personalised information about how you react to medications, which equips you and your healthcare provider with valuable insights to craft at a tailored treatment plan swiftly.
Benefits of PGx testing:
- Avoid ineffective medications
- Improved treatement outcomes
- Minimise the risk of medication side effects
- Optimised drug selection and dosing
- Reduce the likelihood of long term impacts on your health and wellness
- Slash the time and money spent on trial-and error medications
- Get you on fast track to finding the right drug, at the right does, the first time
When Should I have a PGx test done?
- If you are about to start on a medication for the first time
- If you have been on medications in the past and found them not to work
- If you have experienced significant side effects from your medication previously
- Requiring doses of specific medications outside the recommended range
The PGx Multi Panel
Our Pgx Multi panel looks at the genes which are involved in breaking down over 100 different medications, including mental health medications, opioid pain medications, NSAIDs, statins for cardiology, clopidogrel for strokes and stents, proton pump inhibitors for gastroenterology, addiction medicine and others.
You may not need these now, but as your DNA doesn’t change, your results will have lifetime relevance.
PGx Mental Health Medications
The PGx Multi panel looks at gene that are crucial in metabolising medications for mental health conditions.
- Both report on over 80% of mental health medications on the market in Australia
- These include antidepressant, antipsychotics, anxiolytics, ADHD agents, & benzodiazepines
- The report includes specific recommendations based on international guidelines, for what your genetic profile indicates about the best medications for you, and at what dose
Generic Name | Brand Name | Drug Class | Gene |
Agomelatine | Domion, Valdoxan | Antidepressants – other | CYP1A2 |
Amitriptyline | Endep, Entrip | Antidepressants – TCAs | CYP2D6 CYP2C19 |
Aripiprazole | Abilify, Tevaripiprazole, Abyraz, Abilify Maintena | Antipsychotics | CYP2D6 |
Atomoxetine | Strattera | ADHD -miscellaneous agents | CYP2D6 |
Brexpiprazole | Rexulti | Antipsychotics | CYP2D6 |
Bupropion | Zyban SR | Antidepressants – other | CYP2B6 |
Chlorpromazine | Largactil | Antipsychotics | CYP2D6 |
Citalopram | Celapram, Cipramil, Talam | Antidepressants – SSRIs | CYP2C19 |
Clobazam | Frisium | Benzodiazepines | CYP2C19 |
Clomipramine | Anafranil, Placil | Antidepressants – TCAs | CYP2D6 CYP2C19 |
Clozapine | Clopine, Clozaril | Antipsychotics | CYD2D6 CYP1A2 |
Dexamphetamine (a.k.a. Dexamfetamine) | Dexamfetamine | Psychostimulants | CYP2D6 |
Diazepam | Antenex, Valium, Valpam, Diazepam Elixir, Diaze- pam Rectal Solution | Benzodiazepines | CYPC219 |
Dothiepin (a.ka. Dosulepin) | Dothep | Antidepressants – TCAs | CYP2D6 CYP2C19 |
Doxepin | Deptran | Antidepressants – TCAs | CYP2D6 CYP2C19 |
Duloxetine | Cymbalta, Duloxecor, Dytrex, Tixol | Antidepressants – SNRIs | CYP1A2 CYP2D6 |
Escitalopram | Esipram, Lexapro, Cilopam-S, Lexam, Loxalate | Antidepressants – SSRIs | CYP2C19 |
Fluoxetine | Fluotex, Lovan, Prozac, Zactin | Antidepressants – SSRIs | CYP2C9 CYP2D6 |
Fluvoxamine | Faverin, Luvox, Movox | Antidepressants – SSRIs | CYP1A2 CYP2D6 |
Haloperidol | Serenace, Haldol | Antipsychotics | CYP2D6 |
Imipramine | Tofranil | Antidepressants – TCAs | CYP2D6 CYP2C19 |
Lisdexamfetamine | Vyvanse | Psychostimulants | CYP2D6 |
Melatonin | Slenyto, Circadin, Melotin | Hypnotics | CYP1A2 |
Mianserin | Lumin | Antidepressants – other | CYP2D6 |
Mirtazapine | Avanza, Axit, Mirtanza | Antidepressants – other | CYP1A2 CYP2D6 |
Moclobemide | Amira, Aurorix, Clobemix | Antidepressants – other | CYP2C19 |
Nortriptyline | Allegron, NortriTABS | Antidepressants – TCAs | CYP2D6 |
Olanzapine | Ozin, Pryzex, Zypine, Zyprexa, Zypine ODT, Zyprexa Zydis, Zyprexa Relprevv | Antipsychotics | CYP1A2 |
Paroxetine | Paxtine, Aropax, Extine | Antidepressants – SSRIs | CYP2D6 |
Quetiapine | Kaptan, Quetia, Seroquel, Syquet, Quepine XR, Quetia XR, Seroquel XR, Tevatiapine XR | Antipsychotics | CYP3A4 |
Risperidone | Rispa, Risperdal, Ozidal, Rispernia, Rixadone, Risperdal Consta | Antipsychotics | CYP2D6 |
Sertraline | Sertra, Setrona, Eleva, Zoloft | Antidepressants – SSRIs | CYP2C19 CYP2B6 |
Venlafaxine | Efexor-XR, Elaxine-SR, Enlafax-XR | Antidepressants – SNRIs | CYP2D6 |
Vortioxetine | Brintellix | Antidepressants – other | CYP2D6 |
Zuclopenthixol | Clopixol, Clopixol Acuphase, Clopixol Depot | Antipsychotics | CYP2D6 |
Reach your treatment goals sooner on a PGx guided personalised medication plan
$197
PGx Multi
- Incorporates all medications covered in the Mental Health plus opioid pain medications, NSAIDs, cardiology medications, gastroenterology medications, and more.
Results available within 10-15 business days
from receipt in our laboratory.
How to get tested
2. See your doctor to get a request.
See your doctor to get a request form for testing and discuss Pharmacogenomic (PGx) testing with them.
4. See your doctor to get your results
Your results will be sent to your doctor approximately 2 weeks after having your blood collected. Please discuss them with your doctor and ask for a copy of your results.
1. Pay for your test.
Prepay for your test online here or contact our Customer Care team on 1800 822 999. Note that Medicare does NOT cover the cost of testing. Make a note of your receipt number.
2. See your doctor to get a request
See your doctor to get a request form for testing and discuss Pharmacogenomic (PGx) testing with them.
3. Have your sample collected
Write your receipt number on the request form and get your blood collected at your closest Healius Pathology Network* collection centre.
4. See your doctor to get your results
Your results will be sent to your doctor approximately 2 weeks after having your blood collected. Please discuss them with your doctor and ask for a copy of your results.
Pharmacogenomics FAQ
Efficacy of medication is not solely dependent on your DNA. Other factors will impact whether a medication is effective or not and at what dose, including general health, environmental factors, or other medications.
At least 70% of people who have taken a Pharmacogenomic test have a finding that could affect current or future medications.We will send your doctor your report in about 2 weeks from the date of sample collection. Please ask them to share a copy of the report with you.
- https://pubmed.ncbi.nlm.nih.gov/27997040/
- https://pubmed.ncbi.nlm.nih.gov/17074942/
- https://www.painaustralia.org.au/media-1/media-document/enews-1/enews-2017/issue-75/mental-health-a-big-issue-for-people-living-in-pain
Resources
Leading the way to improved health
results in the shortest turnaround time.
